AOD-9604 is a peptide bioregulator of fat metabolism developed on the basis of an active fragment of growth hormone. It is considered as a modern tool for reducing fat mass, improving metabolic health and slowing down the processes of biological aging, without affecting glucose and insulin levels.
AOD-9604 is a synthetic peptide representing a modified fragment of human growth hormone corresponding to site 176-191. The compound is being studied in a research context in connection with metabolic processes and regulation of lipid metabolism. For AOD-9604, commercial and research catalogs usually indicate a short sequence of 16 amino acids with a disulfide bridge between two cysteine residues. https://www.medkoo.com/products/13753?utm_source=chatgpt.com
General information
| Features | Values |
|---|---|
| The peptide sequence | Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe |
| The molecular formula | C78H123N23O23S2 |
| Molecular weight | 1815.1 g/mol |
| CAS Number | 386264-39-7 |
| PubChem CID | 71300630 |
| Synonyms | AOD-9604, AOD9604 |
Lyophilized peptides
All peptides undergo lyophilization, a process that is necessary to extend their shelf life, as well as preserve the purity and integrity of the peptides during storage and transportation. Product Usage: This product is intended solely for research purposes. All product information provided on this website is intended for educational purposes.
Product Usage
This product is intended solely for research purposes. All product information provided on this website is intended for educational purposes.
The purity of peptides is more than 99%
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Without fillers and additives
Only pure active connections. The composition is confirmed by experts for reliable in vitro studies.
AOD-9604 is a synthetic peptide, which is a modified C-terminal fragment of human growth hormone. In the literature, it is usually described as Tyr-hGH 177-191 or as the lipolytic domain of hGH, created to study the effect on fat metabolism without the pronounced effects typical of full-fledged growth hormone on growth and glycemia. In preclinical and early clinical studies, AOD-9604 was considered primarily as a promising molecule for studies of lipolysis, fat oxidation, body weight, and metabolic regulation. Detection and in vitro metabolism of AOD9604 - PubMed
Lipolysis and fat metabolism
The main research area of AOD-9604 is related to the stimulation of the breakdown of adipose tissue. In animal experiments, the peptide reduced body weight gain, increased lipolytic activity in adipose tissue, and increased fat oxidation. In some studies, it has also been shown that its action is associated with beta-adrenergic mechanisms, especially the beta-3-adrenergic pathway, which further supports interest in AOD-9604 as a molecule for studying the regulation of fat metabolism. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone - PubMed
Body weight and obesity research
AOD-9604 has been studied for a long time as a candidate for the correction of obesity. Reviews on the pharmacotherapy of obesity indicate that the peptide was developed specifically as a fragment of growth hormone capable of increasing the breakdown of adipose tissue. Review publications cite data from early clinical trials, where a low dose of oral AOD-9604 showed a more pronounced decrease in body weight in some patients compared with placebo, but later programs did not produce such an unambiguous result, especially against the background of intense diet and physical activity. Therefore, it is more correct for the site to describe it as a research peptide for studying the control of fat mass, rather than as a proven means for weight loss. Safety and Metabolism of AOD9604, a Novel Nutraceutical Ingredient for Improved Metabolic Health | Moré | Journal of Endocrinology and Metabolism
Metabolic selectivity
A separate interest in AOD-9604 is due to the fact that in preclinical studies it did not demonstrate the undesirable metabolic effects typical for full-fledged hGH on insulin sensitivity. In a study on obese Zucker rats, chronic administration of AOD-9604 enhanced lipolysis, but did not worsen insulin sensitivity according to euglycemic clamp, unlike full-fledged growth hormone. Experimental studies have also shown that AOD-9604 does not interact with the classical growth hormone receptor, which emphasizes its separate mechanism of action. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone - PubMed
Cartilage regeneration and orthopedic models
In addition to the metabolic direction, AOD-9604 has also been studied in models of osteoarthritis. In a rabbit model of osteoarthritis, intraarticular injections of AOD-9604 improved cartilage regeneration, and the combination with hyaluronic acid showed a more pronounced effect than the separate use of AOD-9604 or hyaluronic acid. This area is still primarily preclinical, but it makes the peptide interesting for joint tissue repair research. Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model - PubMed
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