Kisspeptin is a family of neuropeptides encoded by the KISS1 gene. The KISS1 gene produces a precursor protein, which is then cleaved into various active fragments, including Kisspeptin-54, -14, -13, and -10. Kisspeptin-10 (KP-10) is the shortest of these fragments, but it retains full biological activity, meaning it can bind to its receptor and activate it. All peptides of kisspeptin, including KP-10, have a common C-terminal decapeptide sequence (arginine-amidated phenylalanine, RFAmide), which is necessary for their biological activity. KP-10 is a universal peptide used in cancer diagnosis, regulation of reproductive function, neuroprotection, regulation of the cardiovascular system and behavioral neurobiology. Its mechanisms include both receptor-dependent and receptor-independent pathways, which confirms its potential as a research and diagnostic tool in various fields.
General information
| Features | Values |
|---|---|
| The peptide sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 |
| The molecular formula | C63H83N17O14 |
| Molecular weight | 1302.4 g/mol |
| CAS Number | 374675-21-5 |
| PubChem CID | 71306396 |
| Synonyms | Kisspeptin, Protein KISS-1, Kisspeptins, Gene KISS1 protein, KISS-1, Metastin |
Product Usage
This product is intended solely for research purposes. All product information provided on this website is intended for educational purposes.
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Kisspeptin -10 is a biologically active peptide fragment of the Kisspeptins family, known for its role in the regulation of reproductive function. Recent research has expanded the scope of its application, revealing diverse effects in oncology, neuroprotection, cardiovascular health, placental biology, and behavioral neurobiology.
Oncology and diagnostic imaging
When labeled with gallium-68 or lutetium-177, KP-10 demonstrates potential as a radiopharmaceutical for cancer diagnosis and therapy. DOTA-KP10 analogues retain their biological activity, while demonstrating rapid elimination from the blood. The researchers are currently optimizing these compounds to increase stability and binding affinity, which supports further development for applications in cancer imaging. KP-10 inhibits the migration of both cancer cells and placental trophoblast cells by modulating key signaling pathways, including GSK3b, FAK, and ERK1/2. This suggests a possible role in suppressing metastasis and regulating placental invasion. The KiSS-1 gene and its peptide products, including kisspeptin-10, are expressed at a lower level in metastatic melanoma compared to non-metastatic forms, suggesting their role in suppressing tumor spread. In addition to melanoma, the KiSS-1/GPR54 system is involved in suppressing metastasis in several other cancers, such as cancers of the stomach, pancreas, ovaries, bladder, and prostate.
Reproductive and endocrine regulation
KP-10 demonstrates powerful stimulation of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone secretion in both animal and human studies. This occurs due to the release of GnRH by the hypothalamus, and the effect depends on the dose. These data indicate the potential importance of KP-10 for understanding reproductive disorders. KP-10 is a physiological inhibitor of trophoblast invasion, subtly regulating placental development and potentially influencing pregnancy outcomes. Neuroprotection and neurological applications KP-10 reduces the development of cerebral aneurysms by inhibiting Egr-1, MMP-9, VEGF-A and macrophage infiltration by acting through the GPR54 receptor. The KP-10/GPR54 system may be important for understanding diseases of the blood vessels of the brain. KP-10 protects cholinergic neurons from alpha-synuclein-induced toxicity and mitochondrial apoptosis, which is related to diseases such as Lewy body dementia. Some neuroprotective effects are manifested independently of the GPR54 receptor, which indicates a direct interaction of the peptide with the protein.
Effects on the cardiovascular system and behavior
KP-10 increases the collagen content in the myocardium by activating FAK, affecting cardiac fibrosis by stimulating collagen synthesis and inhibiting matrix metalloproteinases. Animal studies show that KP-10 alters impulsive behavior, compulsive actions, and reward responses. These effects are related to brain chemicals such as dopamine and serotonin. This indicates potential relevance for research in decision-making and compulsive disorders.
Links
1. Reeve, R., Marjanovic-Painter, B., Kleynhans, J., Driver, C., Millar, R., Ebenhan, T., Zeevaart, J., & Sathekge, M. (2025). Synthesis and characterisation of DOTA‐kisspeptin‐10 as a potential gallium‐68/lutetium‐177 pan‐tumour radiopharmaceutical. Journal of Neuroendocrinology, 37. https://doi.org/10.1111/jne.13487.
2. Roseweir, A., Millar, R., Millar, R., Millar, R., Katz, A., & Katz, A. (2012). Kisspeptin-10 inhibits cell migration in vitro via a receptor-GSK3 beta-FAK feedback loop in HTR8SVneo cells.. Placenta, 33 5, 408-15 . https://doi.org/10.1016/j.placenta.2012.02.001.
3. Song, Y., Ni, Y., Ding, L., Zhu, N., & Zhao, M. (2020). The KiSS-1/GPR54 system: Essential roles in physiological homeostasis and cancer biology. Genes & Diseases, 9, 28 – 40. https://doi.org/10.1016/j.gendis.2020.07.008.
4. Smith, K., Murphy, K., Patterson, M., Thompson, E., Ghatei, M., Dhillo, W., Todd, J., & Bloom, S. (2004). Central and Peripheral Administration of Kisspeptin‐10 Stimulates the Hypothalamic‐Pituitary‐Gonadal Axis. Journal of Neuroendocrinology, 16. https://doi.org/10.1111/J.1365-2826.2004.01240.X.
5. Ghaffari‐Tabrizi, N., Molzer, S., Andreae, F., Graier, W., Hiden, U., Malli, R., Desoye, G., Hintermann, E., Zoratti, C., Wagner, O., Quaranta, V., Sharabi, A., Bilban, M., Bauer, S., & Knöfler, M. (2004). Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts. Journal of Cell Science, 117, 1319 – 1328. https://doi.org/10.1242/jcs.00971.
6. Liufu, X. (2025). Kisspeptin-10 Prevents the Development of Cerebral Aneurysms by Reducing the Expression of Egr-1.. CNS neuroscience & therapeutics, 31 5, e70413 . https://doi.org/10.1111/cns.70413.
7. Ahemad, N., Simon, C., Bhuvanendran, S., Soga, T., & Parhar, I. (2022). Kisspeptin-10 Rescues Cholinergic Differentiated SHSY-5Y Cells from α-Synuclein-Induced Toxicity In Vitro. International Journal of Molecular Sciences, 23. https://doi.org/10.3390/ijms23095193.
8. Drobnik, J., Gałdyszyńska, M., Radwańska, P., & Piera, L. (2023). Kisspeptin-10 increases collagen content in the myocardium by focal adhesion kinase activity. Scientific Reports, 13. https://doi.org/10.1038/s41598-023-47224-3. 9. Lebedev, A., Bychkov, E., Shabanov, P., & Pyurveev, S. (2025). Pharmacological analysis of the role of kisspeptin-10 in reinforcing mechanisms. Research Results in Pharmacology. https://doi.org/10.18413/rrpharmacology.11.544.
