Matrixyl is a cosmetic signaling peptide, most commonly palmitoyl pentapeptide-4, which is used in skin care formulas. It is used in anti-aging products, as it is studied in the context of supporting collagen synthesis, increasing skin elasticity and reducing the severity of fine wrinkles.
Matrixyl is a cosmetic signaling peptide known as Palmitoyl Pentapeptide-4. This compound is a KTTKS peptide bound to palmitic acid, which increases its lipophilicity and makes it convenient for use in cosmetic formulas. In the research and cosmetology context, Matrixyl is being studied in connection with supporting the extracellular matrix of the skin, stimulating collagen synthesis, and improving the appearance of the skin with age-related changes.
General information
| Features | Values |
|---|---|
| The peptide sequence | Pal-Lys-Thr-Thr-Lys-Ser-OH |
| The molecular formula | C39H75N7O10 |
| Molecular weight | 802.05 g/mol |
| CAS Number | 214047-00-4 |
| PubChem CID | 9897237 |
| Synonyms | Matrixyl, Palmitoyl Pentapeptide-4, Palmitoyl Pentapeptide-3, Pal-KTTKS |
Lyophilized peptides
All peptides undergo lyophilization, a process that is necessary to extend their shelf life, as well as preserve the purity and integrity of the peptides during storage and transportation. Product Usage: This product is intended solely for research purposes. All product information provided on this website is intended for educational purposes.
Product Usage
This product is intended solely for research purposes. All product information provided on this website is intended for educational purposes.
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Matrixyl is a signaling cosmetic peptide most commonly identified with palmitoyl pentapeptide-4, known as Pal-KTTKS. It is a lipophilic form of a peptide fragment created for better penetration into the skin and stimulation of extracellular matrix components. Scientific reviews describe Matrixyl as one of the most well-known signaling peptides in cosmetology, used primarily in studies of age-related skin changes, wrinkles, restoration of the dermal matrix and maintenance of the skin barrier. It is important not to confuse classic Matrixyl with Matrixyl 3000, as this is a different peptide complex. Current Approaches in Cosmeceuticals: Peptides, Biotics and Marine Biopolymers - PMC
Anti-aging effect
The main research area of Matrixyl is related to reducing the severity of wrinkles and improving the visual parameters of photo-damaged skin. In a clinical trial involving 93 women aged 35-55 years, palmitoyl pentapeptide showed a statistically significant improvement in fine lines and wrinkles compared with placebo after 12 weeks of use. Reviews of cosmetic peptides also cite Matrixyl as one of the earliest and most studied signaling peptides for external anti-age care. Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin - PubMed
Stimulation of collagen and extracellular matrix
Matrixyl is being investigated primarily as a peptide capable of stimulating the synthesis of structural components of the dermis. According to reviews, Pal-KTTKS promotes increased collagen production, in particular types I and III, and can also support the synthesis of elastin, fibronectin, and glycosaminoglycans. Mechanically, it belongs to signaling peptides that mimic natural matrix signals and activate fibroblasts, enhancing the renewal of the extracellular matrix. Current Approaches in Cosmeceuticals: Peptides, Biotics and Marine Biopolymers - PMC
Skin penetration and structural features
The key feature of Matrixyl is the attachment of a palmitoyl group to a short peptide fragment of KTTKS. This modification makes the molecule more lipophilic and increases its ability to cross the stratum corneum, which is an important limitation for conventional hydrophilic peptides. Matrixyl is described in publications as Pal-Lys-Thr-Thr-Lys-Ser-OH, where the palmitoyl residue increases stability and improves active signal delivery to the skin. Matrixyl Patch vs Matrixyl Cream: A Comparative In Vivo Investigation of Matrixyl (MTI) Effect on Wound Healing - PMC
Skin repair and healing
In addition to the anti-aging field, Matrixyl is being studied in skin repair models. In experimental work on wound healing, palmitoyl pentapeptide was associated with more active epithelialization, increased collagen formation, and favorable dynamics of angiogenesis in the injury area. The authors also discussed the potential of the peptide in the context of regulating scarring and restoring tissue architecture, although these data so far relate more to experimental models than to standard clinical practice. Matrixyl Patch vs Matrixyl Cream: A Comparative In Vivo Investigation of Matrixyl (MTI) Effect on Wound Healing - PMC
Cosmetological value and limitations
Matrixyl remains primarily a cosmetic and research peptide for external use. The most convincing data on it concerns the improvement of skin appearance, fine wrinkles and texture, rather than systemic action. Therefore, it is more correct for the site to describe it as a peptide for anti-age care research, support of collagen synthesis and restoration of the extracellular matrix of the skin, without overstated therapeutic claims. Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin - PubMed
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