Melanotan-1 is a synthetic peptide that affects the melanocortin system with a predominant effect on melanin production. It was originally developed as a molecule for photoprotection and protection of the skin from ultraviolet damage, rather than as a means of rapid cosmetic tanning. Unlike Melanotan-2, Melanotan-1 acts more selectively and mildly. It stimulates a gradual and uniform increase in melanin levels, due to which a tan forms slowly and looks natural, without sudden jumps in pigmentation and a pronounced effect on the central nervous system. This makes it a more controlled tool when working specifically with skin and photosensitivity. The key value of Melanotan-1 is the combination of pigmentation and protective effect. An increase in melanin levels is accompanied by an increase in the skin's resistance to ultraviolet radiation, which is of interest in protocols related to photoaging, skin damage, and reduced UV exposure. For this reason, Melanotan-1 is considered not only as an aesthetic, but also as a protective molecule, and it is important to take into account individual skin reactions. Against the background of the use of Melanotan-1, pigmentation changes may occur in some people, including darkening of existing moles, increased severity of age spots, as well as the appearance of new pigmented areas. These effects are related to the general activation of melanocytes and depend on the genetic predisposition and the initial condition of the skin. The use of Melanotan-1 is not recommended for people with a history of melanoma, as well as in the presence of suspicious or undiagnosed skin growths. In protocols with long-term use, special attention is paid to the control of skin changes and pigmented elements. Unlike Melanotan-2, Melanotan-1 has virtually no effect on libido, appetite, or behavioral responses. It is used in cases where pigmentation and photoprotection are required without pronounced central effects. In complex aesthetic and antiage protocols, Melanotan-1 can be combined with peptides aimed at skin quality and regeneration, including GHK-Cu, enhancing the visual effect by improving the structure and density of the skin. Melanotan-1 is not a "peptide for rapid tanning", but a tool for controlled work with pigmentation and photosensitivity of the skin, requiring a conscious approach and understanding of possible individual reactions.
General information
| Features | Values |
|---|---|
| The peptide sequence | Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 |
| The molecular formula | C78H111N21O19 |
| Molecular weight | 1646.8 g/mol |
| CAS Number | 75921-69-6 |
| PubChem CID | 16164658 |
| Synonyms | Melanotan-1, Afamelanotide, NDP-MSH, [Nle4,D-Phe7]-α-MSH |
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Product Usage
This product is intended solely for research purposes. All product information provided on this website is intended for educational purposes.
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Melanotan 1 is a synthetic analogue of α-MSH, more correctly known in the scientific and clinical literature as afamelanotide. It acts as an agonist of the melanocortin MC1R receptor and is studied primarily in the context of photoprotection, enhanced eumelanin synthesis, skin pigmentation, and conditions associated with hypersensitivity to light. It is important not to confuse Melanotan 1 with Melanotan 2, as these are different molecules with different action profiles. To date, afamelanotide has been registered in the USA and a number of other countries in the form of a SCENESSE implant to increase pain-free exposure to light in adult patients with erythropoietic protoporphyria. label
Photoprotection and erythropoietic protoporphyria
The main research area of Melanotan 1 is related to photoprotection. By activating MC1R and enhancing eumelanin synthesis, the molecule increases the skin's natural resistance to light exposure. In clinical studies in patients with erythropoietic protoporphyria, afamelanotide increased light tolerance and improved quality of life, which became the basis for its registered use. Afamelanotide for Erythropoietic Protoporphyria - PMC
Skin pigmentation and MC1R
Melanotan 1 is being investigated as a selective stimulator of melanogenesis through MC1R. This receptor plays a key role in switching pigment synthesis towards eumelanin, which is considered more photoprotective than pheomelanin. The reviews on MC1R and afamelanotide emphasize that such stimulation is associated not only with increased pigmentation, but also with an improvement in some cellular mechanisms of response to UV damage. Melanocortin 1 Receptor (MC1R): Pharmacological and Therapeutic Aspects - PMC
Vitiligo and repigmentation
A separate area of afamelanotide research is related to vitiligo, especially in combination with narrowband UVB. In clinical studies, the combination of afamelanotide with NB-UVB provided faster and more pronounced pigment restoration compared with phototherapy alone, especially in patients with darker skin phototypes. This makes Melanotan 1 an interesting research molecule for studying pigmentation disorders and supporting repigmentation. Afamelanotide and narrowband UV-B phototherapy for the treatment of vitiligo: a randomized multicenter trial - PubMed
Anti-inflammatory and dermatological potential
In addition to affecting pigmentation, MC1R signaling is associated with anti-inflammatory effects in the skin. Current reviews note that chronic activation of MC1R may be of interest in the context of photodamage, inflammatory skin conditions, and control of cellular response to UV stress. At the same time, these areas are still largely research-based and should not be presented as already confirmed broad clinical indications. An overview of benefits and risks of chronic melanocortin‐1 receptor activation - PMC
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