Melanotan-2 is a peptide bioregulator of the melanocortin system with a multidirectional effect on skin, pigmentation and neurohormonal processes. It activates the production of melanin, increasing the natural photoprotection of the skin and contributing to the formation of an even, saturated tan without excessive sun exposure. In addition to its aesthetic effect, Melanotan-2 affects neuroregulation, appetite and libido, which makes it interesting not only in a cosmetic, but also in a metabolic and neuroendocrine context. The peptide works through central mechanisms rather than surface stimuli. It is used in skin quality improvement programs, photoprotection, and complex protocols where the relationship of appearance with internal regulation and hormonal balance is important. Melanotan-2 is a peptide for those who consider skin and aesthetics as a reflection of the body's systemic processes.
General information
| Features | Values |
|---|---|
| The peptide sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 |
| The molecular formula | C50H69N15O9 |
| Molecular weight | 1024.2 g/mol |
| CAS Number | 121062-08-6 |
| PubChem CID |
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| Synonyms | Melanotan II, Melanotan 2, MT-II, MT-2, MT2 |
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All peptides undergo lyophilization, a process that is necessary to extend their shelf life, as well as preserve the purity and integrity of the peptides during storage and transportation. Product Usage: This product is intended solely for research purposes. All product information provided on this website is intended for educational purposes.
Product Usage
This product is intended solely for research purposes. All product information provided on this website is intended for educational purposes.
The purity of peptides is more than 99%
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Without fillers and additives
Only pure active connections. The composition is confirmed by experts for reliable in vitro studies.
Melanotan 2 is a synthetic cyclic analogue of α-MSH and a non-selective agonist of melanocortin receptors, which has been studied primarily in the context of enhanced skin pigmentation, sexual function, and central neuromodulation. Unlike Melanotan 1, more correctly known as afamelanotide, Melanotan 2 acts more broadly and affects not only MC1R, but also other subtypes of melanocortin receptors, therefore its profile is considered more pronounced, but less selective. Overview of the benefits and risks of chronic activation of melanocortin-1 — PMC receptors
The main interest in Melanotan 2 is related to skin pigmentation and increased tanning, since it stimulates melanogenesis through the activation of melanocortin receptors. That is why it became known as tanning peptide, although this practice cannot be equated with proven safe photoprotection. Modern reviews on the melanocortin system emphasize that the cosmetic use of such agonists requires caution, especially against the background of UV exposure. Overview of the benefits and risks of chronic activation of melanocortin-1 — PMC receptors
The second important area of research is related to sexual function. Early clinical studies have shown that Melanotan II is able to induce an erectile response and enhance sexual arousal in some men. It was from this line of research that interest in more specialized melanocortin molecules, including PT-141, later grew. In clinical publications for Melanotan II, nausea and yawning were described among the common side effects against this background. Synthetic melanotropic peptide initiates erection in men with psychogenic erectile dysfunction: a double-blind, placebo-controlled crossover study — PubMed
Due to its central action through melanocortin receptors, Melanotan 2 has also attracted interest as a molecule for studying appetite, body weight, and behavioral regulation, but it is better to indicate this carefully for the site, because this is not its main and unconfirmed clinical niche. Due to its non-selectivity and central action, it can have effects such as decreased appetite, fatigue, and changes in libido. Overview of the benefits and risks of chronic activation of melanocortin-1 — PMC receptors
From the point of view of risks, Melanotan 2 must be served especially carefully. There are reports in the literature of darkening and alteration of existing nevi, as well as individual case reports of melanoma in situ and melanoma due to the use of Melanotan II, often in combination with tanning or intense UV exposure. These publications do not prove direct causation, but they are enough to avoid describing the peptide as a safe cosmetic tool. Melanotan—associated melanoma in situ - PubMed
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