PT-141 is a centrally acting peptide bioregulator that affects the melanocortin system of the brain and directly affects sexual desire, motivation, and emotional response. It is one of the few peptide molecules that have undergone a full cycle of clinical trials and received FDA approval for the treatment of hypoactive sexual desire disorder in women.
PT-141 is a synthetic peptide, also known as bremelanotide, which belongs to the melanocortin receptor agonists and is being studied primarily in the context of sexual function, central neuromodulation and regulation of sexual behavior. Unlike classical drugs that act through a vascular mechanism, PT-141 works primarily at the level of the central nervous system through the melanocortin system, which has made it a particularly prominent molecule in studies of libido and sexual response. The most studied areas are related to female hypoactive sexual desire disorder and erectile dysfunction in men, but it is more correct for the site to describe it more broadly as a research peptide for studying melanocortin regulation of sexual behavior and neuroendocrine processes.
General information
| Features | Values |
|---|---|
| The peptide sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
| The molecular formula | C50H68N14O10 |
| Molecular weight | 1025.2 g/mol |
| CAS Number | 189691-06-3 |
| PubChem CID |
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| Synonyms |
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Product Usage
This product is intended solely for research purposes. All product information provided on this website is intended for educational purposes.
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PT-141 is a neuropeptide with a targeted effect on the centers of libido and sexual motivation, working through the central nervous system, rather than through the hormonal background. It affects the melanocortin system of the brain, enhancing sexual desire and sensitivity. The key feature of PT-141 is its independence from the level of sex hormones and blood flow. The peptide affects the neural mechanisms of arousal and interest, which makes it universal for men and women, including for stressful and psychoemotional causes of decreased libido. PT-141 is used in programs to restore sexual health, neuroendocrine balance, and quality of life, where natural sensations are important rather than mechanical stimulation. PT-141 is a peptide for restoring desire, sensitivity, and a living connection between the body and the brain.
Sexual desire and libido
The main research area of PT-141 is related to its ability to enhance sexual desire and central sexual motivation. This is how it differs from peripheral vasoactive drugs, since it does not affect blood vessels directly, but rather the neuronal mechanisms of excitation. In clinical studies, bremelanotide has shown interest primarily in models of decreased sexual desire in women, thereby forming its main research and clinical niche. Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials - PubMed
Erectile function
PT-141 has also been studied in men with erectile dysfunction, especially in situations where not only a vascular but also a central component of the response was required. The research interest in the molecule was related to the fact that activation of melanocortin receptors can enhance sexual arousal and erectile response through central pathways. This made PT-141 one of the few peptide molecules studied in sexual medicine specifically as a central regulator. Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction - PubMed
Melanocortin system and mechanism of action
Pharmacologically, PT-141 is of interest as an agonist of melanocortin receptors, mainly MC4R, as well as to a lesser extent other subtypes. The melanocortin system is involved not only in sexual behavior, but also in the regulation of appetite, energy balance, mood, and autonomic reactions. Therefore, PT-141 is important not just as a molecule for libido, but as a tool for studying the broader neuropeptide regulation of motivation and behavior. The neurobiology of bremelanotide for the treatment of hypoactive sexual desire disorder in premenopausal women - PubMed
Neuroendocrine regulation
A special interest in PT-141 is related to the fact that it acts through central circuits involved in the integration of emotional, hormonal, and motivational signals. Due to this, it is considered as a research molecule at the junction of neuroendocrinology and behavioral physiology. This mechanism makes PT-141 particularly interesting in comparison with compounds that work only through peripheral hemodynamics.
Female sexual function
The most well-known area of clinical study of PT-141 is related to the hypoactive sexual desire disorder in premenopausal women. It is in this direction that the molecule has received the greatest development, and the accumulated data have supported interest in central melanocortin modulation as a separate strategy in sexual medicine. This is convenient for the description on the website, because it allows you to show PT-141 as a peptide with an already well-defined field of study, but without unnecessarily direct promises of results.
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