Selank is a synthetic heptapeptide based on the endogenous regulatory peptide tuftsin. It belongs to the class of neuropeptide bioregulators and is used to normalize anxiety, support cognitive functions, immune regulation and increase stress resistance. Selank combines anxiolytic and mild nootropic effects without a pronounced sedative effect, which makes it in demand in modern health and longevity programs.
Selank is an anxiolytic neuropeptide with a mild regulating effect on the central nervous system, created to reduce anxiety and emotional tension without sedative effect. It helps to stabilize the psycho-emotional state, improves adaptation to stress and maintains clarity of thinking even under conditions of chronic stress. Selank normalizes the balance of neurotransmitters, reduces internal tension and at the same time does not cause drowsiness, addiction or decreased performance. The peptide is widely used in anti-stress support programs, recovery after emotional burnout, and in complex protocols for neurobalance and quality of life. Selank is a solution for calmness, concentration and stability in the rhythm of modern life.
General information
| Features | Values |
|---|---|
| The peptide sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro |
| The molecular formula | C33H57N11O9 |
| Molecular weight | 751.9 g/mol |
| CAS Number | 129954-34-3 |
| PubChem CID | 11765600 |
| Synonyms | Selank, TKPRPGP |
Lyophilized peptides
All peptides undergo lyophilization, a process that is necessary to extend their shelf life, as well as preserve the purity and integrity of the peptides during storage and transportation. Product Usage: This product is intended solely for research purposes. All product information provided on this website is intended for educational purposes.
Product Usage
This product is intended solely for research purposes. All product information provided on this website is intended for educational purposes.
The purity of peptides is more than 99%
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Selank is a synthetic heptapeptide Thr-Lys-Pro-Arg-Pro-Gly-Pro, created on the basis of the immunomodulatory peptide tuftsin and considered primarily as a neuropeptide with anxiolytic, stress-protective and neuromodulating potential. Scientific publications describe Selank as a molecule associated with the regulation of the GABAergic system, neurotrophins, and immune signals, while the main evidence base on it is concentrated in preclinical studies and relatively small clinical trials. Therefore, it is more correct for the site to present it as a research peptide for studying anxiety, neuroplasticity, cognitive functions and stress-associated conditions, without excessive promises. Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity - PubMed
Anxiolytic effect
The main research area of Selank is related to the reduction of anxiety and stress-associated behavioral disorders. Clinical and experimental publications reported that Selank showed anxiolytic activity, and in a number of studies its effect was discussed as comparable in direction with classical anxiolytics, but with a different mechanism of action. In the model of chronic unpredictable stress, Selank reduced anxiety-like behavior, and in combination with diazepam even enhanced its anti-stress effect. [Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia] - PubMed
GABAergic-system and mechanism of action
One of the most frequently discussed Selank mechanisms is related to the modulation of GABAergic neurotransmission. Studies of gene expression have shown that after the introduction of Selank, the expression of a number of genes involved in neurotransmission changes, and the authors directly point to a possible connection between its action and the allosteric modulation of the GABAergic system. Separate studies have also shown that Selank can alter the response to GABA and pharmacological agents that affect GABA receptors. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission - PMC
BDNF and neuroplasticity
Selank is also interesting as a peptide that affects neuroplasticity. In experimental work after intranasal administration, it was shown that it regulates the expression of BDNF in the hippocampus, and this connects Selank with the processes of learning, adaptation, and repair of nervous tissue. That is why it is often referred to not only as anxiolytic, but also as nootropic-neuromodulating research peptides. Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo - PubMed
Cognitive functions and stress-protective potential
In addition to anxiety, Selank has been studied in models of cognitive impairment and stress. Animal studies have described improvements in learning and memory processes, as well as protection against stress-induced behavioral changes. Separate studies have shown that Selank can weaken memory and attention disorders in models of alcohol withdrawal, which additionally supports interest in it as a peptide for studying the adaptive capabilities of the central nervous system. The Optimizing Action of the Synthetic Peptide Selank on a Conditioned Active Avoidance Reflex in Rats | Neuroscience and Behavioral Physiology | Springer Nature Link
Immunomodulation and cytokines
Another important area is related to the immunomodulatory properties of Selank. It has been reported in publications that it affects cytokine levels under conditions of social stress, which makes it possible to consider it as a molecule at the junction of neuroimmunology and stress biology. This combination of neuromodulatory and immunoregulatory profiles makes Selank particularly interesting for research on chronic stress and related disorders. The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress - PubMed
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