Semax is a neuropeptide with pronounced nootropic and neuroprotective effects, developed to support the brain under stress, high loads and age-related changes. It improves cognitive functions, increases concentration, clarity of thinking and resistance to mental fatigue, without causing dependence and exhaustion of the nervous system. Semax gently enhances neuroplasticity, supports the work of neurotransmitters and helps the brain adapt to stress factors. The peptide is widely used in productivity enhancement programs, recovery from emotional and intellectual overload, as well as in complex protocols for neuropreservation and active longevity. Semax is a tool for those who need a clear head, stable psychoemotional form and maximum cognitive resource every day.
General information
| Features | Values |
|---|---|
| The peptide sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| The molecular formula | C37H51N9O10S |
| Molecular weight | 813.9 g/mol |
| CAS Number | 80714-61-0 |
| PubChem CID | 122178 |
| Synonyms | Semax, MEHFPGP, H-Met-Glu-His-Phe-Pro-Gly-Pro-OH, ACTH(4-10) analog |
Lyophilized peptides
All peptides undergo lyophilization, a process that is necessary to extend their shelf life, as well as preserve the purity and integrity of the peptides during storage and transportation. Product Usage: This product is intended solely for research purposes. All product information provided on this website is intended for educational purposes.
Product Usage
This product is intended solely for research purposes. All product information provided on this website is intended for educational purposes.
The purity of peptides is more than 99%
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Without fillers and additives
Only pure active connections. The composition is confirmed by experts for reliable in vitro studies.
Semax is a synthetic neuropeptide based on the ACTH fragment(4-7) with the addition of Pro-Gly-Pro to increase resistance to enzymatic degradation. In the literature, it is usually referred to as Met-Glu-His-Phe-Pro-Gly-Pro, rather than as the classic hormonal ACTH peptide, since Semax does not exhibit pronounced hormonal activity and is considered primarily as a neuroprotective and neuromodulating molecule. His main interest is related to the research of ischemic brain damage, cognitive functions, BDNF-dependent neuroplasticity and stress-associated disorders. The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer’s Disease - PMC
Neuroprotection and ischemic brain damage
The main research area of Semax is related to neuroprotection in cerebral ischemia. In clinical and preclinical studies, it was reported that Semax improved recovery in the acute period of ischemic stroke, and was also accompanied by more favorable dynamics of neurological deficits and motor functions. Later publications additionally associate this effect with the effect on neurotrophins, immune response, and vascular processes in ischemic brain tissue. [Effectiveness of semax in acute period of hemispheric ischemic stroke (a clinical and electrophysiological study)] - PubMed
BDNF, TrkB, and neuroplasticity
One of the most interesting Semax mechanisms is related to the modulation of BDNF/TrkB signaling. Experimental studies have shown that the peptide increased the expression of BDNF and related receptors in the hippocampus and cortex, as well as affected the expression of other neurotrophins in ischemic damage. This is why Semax is often considered as a research molecule for studying memory, learning, damage recovery, and general neuroplasticity. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus - PubMed
Cognitive function and stress
Semax is also being studied in the context of cognitive impairment and stress-related behavioral changes. It has been described in review and experimental publications that it can facilitate learning, support memory, and reduce the effects of stress-induced cognitive impairment in animal models. Due to this, Semax is considered one of the neuropeptides that are of interest not only for vascular neurology, but also for broader studies of brain adaptation to stress and damage. Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia–Reperfusion in Rats - PMC
Immunomodulation and vascular processes
Another important area is related to the fact that Semax affects not only neurons. According to transcriptomic studies, in ischemia, it alters the expression of genes associated with the immune response, immune cell mobility, chemokines, and vascular processes. This makes it particularly interesting as a multi-target research peptide, where neuroprotection is probably associated not with a single mechanism, but with a combination of neurotrophic, immune, and angiomodulatory activity. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis - PMC
Ophthalmology department
There is also a separate ophthalmological research area for Semax. Early clinical publications reported positive dynamics in diseases of the optic nerve, including improvements in visual function and conduction. This is not the largest part of the evidence base, but it shows that the research interest in the molecule went beyond just stroke and cognitive models. [Evaluation of therapeutic effect of new Russian drug semax in optic nerve disease] - PubMed
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