TB-500 is a regenerative peptide that is most often chosen to accelerate tissue repair, reduce inflammation, and improve the quality of rehabilitation after injury and overload. TB-500 works particularly well in combinations, where it enhances the recovery “background” and makes protocols more complex.
TB-500 is a synthetic N-acetylated heptapeptide corresponding to the active fragment of Thymosin Beta-4 [17-23]. In the research context, TB-500 is being studied in connection with the processes of cell migration, tissue repair, and actin-binding mechanisms. Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential
General information
| Features | Values |
|---|---|
| The peptide sequence | Ac-Lys-Lys-Thr-Glu-Thr-Gln-Glu |
| The molecular formula | C38H68N10O14 |
| Molecular weight | 889.0 g/mol |
| CAS Number | 885340-08-9 |
| PubChem CID | 62707662 |
| Synonyms | TB-500, TB500, Thymosin β4 fragment 17-23, Ac-LKKTETQ |
Lyophilized peptides
All peptides undergo lyophilization, a process that is necessary to extend their shelf life, as well as preserve the purity and integrity of the peptides during storage and transportation. Product Usage: This product is intended solely for research purposes. All product information provided on this website is intended for educational purposes.
Product Usage
This product is intended solely for research purposes. All product information provided on this website is intended for educational purposes.
The purity of peptides is more than 99%
Confirmed by certified laboratories. The analysis certificates are available before purchase.
GMR Production Standards
Manufactured in enterprises in accordance with good manufacturing practices. Complete documentation on tracking the origin of the product.
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Sending orders the next day at checkout before 12:00 Moscow time. Free standard shipping across the country for orders starting from 15,000₽ (or equivalent).
Without fillers and additives
Only pure active connections. The composition is confirmed by experts for reliable in vitro studies.
TB-500 is a versatile peptide used in various therapeutic areas, including liver disease, eye health, tissue regeneration, cardiovascular system, and rejuvenation. Its ability to promote cell survival, reduce inflammation, and enhance tissue regeneration makes it a promising candidate for future research.
Wound healing
The main interest in TB-500 is related to research on tissue healing, angiogenesis, and cell migration. For thymosin beta-4, accelerated reepithelialization, increased wound contraction, and faster recovery of full-layered skin lesions in animals have been shown. In some studies, Tß4 also improved the organization of collagen and promoted more mature remodeling of connective tissue, which generated interest in short active fragments of this molecule. Thymosin beta4 accelerates wound healing - PubMed
Repair of muscles, tendons and ligaments
TB-500 is usually attributed to peptides that are studied in the context of sports injuries and soft tissue injuries, but here, again, the most convincing data are obtained for thymosin beta-4. In muscle models, Tß4 accelerated damage closure and enhanced myoblast chemotaxis, and in the medial collateral ligament injury model, its administration improved ligament repair. It is these data that are most often used as a scientific justification for the interest in TB-500 in regenerative protocols. Muscle injury-induced thymosin β4 acts as a chemoattractant for myoblasts - PubMed
Angiogenesis and cell migration
The regenerative value of TB-500 is usually associated with the biology of thymosin beta-4, which is described in reviews as a multifunctional regenerative peptide with angiogenic properties. Increased cell migration, participation in the restoration of the vascular network, and support of repair processes after damage have been shown for Tß4. Due to this, TB-500 is often positioned on the market as a peptide for systemic recovery, although it is more correct to say that this logic is primarily based on data on full-length Tb4. Progress on the Function and Application of Thymosin β4 - PMC
Anti-inflammatory potential
Another important area is related to the control of inflammation. In reviews and experimental studies, thymosin beta-4 was associated with a decrease in inflammatory signals, an effect on NF-kB-dependent pathways, a restriction of IL-8 production, and a general mitigation of the inflammatory response in various tissues. This supports the interest in TB-500 as a research peptide for models of inflammatory damage, but direct extrapolation from Tß4 to TB-500 should be done cautiously. Thymosin β4 inhibits TNF-α-induced NF-κB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK - PMC
Ocular surface and epithelial repair
Good data on the cornea and ocular surface have also been accumulated for thymosin beta-4. In reviews and clinical publications, Tß4 accelerated corneal healing, reduced inflammation after injury, and was studied in dry eye and neurotrophic keratitis. These results are important for the general characterization of the class, as they show how extensively the reparative properties of thymosin beta-4 have been studied, which led to interest in its short fragments and derivatives. Thymosin beta4 and corneal wound healing: visions of the future - PubMed
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